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主营:临床生物学、分子生物学、实验室设备、耗材、免疫学及免疫血液等
℡ 4000-520-616
℡ 4000-520-616
Biovendor/sCD40 Ligand Murine E. coli/RBG20060025/25 µg
产品编号:RBG20060025
市  场 价:¥0.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:待定
品      牌: Biovendor
公      司:Biovendor-Laboratorni
公司分类:
Biovendor/sCD40 Ligand Murine E. coli/RBG20060025/25 µg
商品介绍
  • Regulatorystatus:RUO
  • Type:Recombinant
  • Source:E.coli
  • Othernames:solubleCD40Ligand,TNFSF5,TRAP,CD154,gp39,T-BAM
  • Species:Murine

Type

Recombinant

Description

CD40,amemberoftheTNFreceptorfamily,isacellsurfaceproteinexpressedonBcells,dendriticcells,monocytes,thymicepithelialcellsand,atlowlevels,onTcells.SignalingthoughCD40playsanimportantroleintheproliferationanddifferentiationofBcells,andiscriticalforimmunoglobulin(Ig)classswitching.Themembrane-anchoredCD40-LigandisexpressedalmostexclusivelyonactivatedCD4+Tlymphocytes.FailuretoexpressCD40Lleadsto“immunodeficiencywithhyper-IgM”,adiseasecharacterizedbyfailuretoproduceIgG,IgAandIgE.ThesolubleformofCD40Lisan18kDaproteincomprisingtheentireTNFhomologousregionofCD40LandisgeneratedinvivobyanintracellularproteolyticprocessingofthefulllengthCD40L.RecombinantMurineCD40Lisasoluble16.4 kDaproteincontaining149 aminoacidresiduescomprisingthereceptorbindingTNF-likedomainof CD40L.

AminoAcidSequence

MQRGDEDPQIAAHVVSEANSNAASVLQWAKKGYYTMKSNLVMLENGKQLTVKREGLYYVYTQVTFCSNREPSSQRPFIVGLWLKPSSGSERILLKAANTHSSSQLCEQQSVHLGGVFELQAGASVFVNVTEASQVIHRVGFSSFGLLKL

Source

E.coli

Purity

98%

BIOLOGicalActivity

DeterminedbyitsABIlitytoinduceTNF-αandMIP-1αproductionbymurinesplenocytes.TheexpectedED50forthiseffectis<0.1 µg/ml.

Endotoxin

Endotoxinlevelis<0.1 ng/μgofprotein(<1EU/μg).

Reconstitution

Centrifugethevialpriortoopening.Reconstituteinwatertoaconcentrationof0.1–1.0 mg/ml.Donotvortex.Forextendedstorage,itisrecommendedtofurtherdiluteinabuffercontainingacarrierprotein(example0.1%BSA)andstoreinworkingaliquotsat –20°Cto –80°C

Storage/Expiration

 –20°C

品牌介绍

BioVendor LM的这个部门是国际活跃的 生物技术公司拥有自己的研究,开发和制造以及国际销售和营销网络。它专门开发用于检测新型激素样蛋白和蛋白生物标志物以及相关抗体和重组蛋白的原始免疫分析试剂盒。最近,我们还专注于在科学和诊断界中广为关注的新主题-microRNA生物标志物,液体活检,外来体分离以及免疫诊断复用和自动化。

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